2025 Syllabus Materials
Controversies & Advances in the Treatment of Cardiovascular DiseaseJanuary 30 – 31, 2025
The Beverly Hills Hotel | 9641 Sunset Blvd | Beverly Hills, CA 90210
Sessions – Crystal Ballroom
Lunches – Rodeo Ballroom
Map of the hotel
COURSE MATERIALS
Educational Grants & Corporate Support Acknowledgements
Educational Grant Support
This program is supported, in part, by educational grants from industry, in accordance with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. We gratefully acknowledge and thank the following contributors who have given generously to support this symposium.
Abbott
Biosense Webster, Inc.
Boston Scientific
Edwards Lifesciences
HeartFlow
J&J MedTech, Heart Recovery
Medtronic
Zimmer Biomet
Exhibitor Acknowledgements
PLATINUM EXHIBITOR
Edwards Lifesciences
GOLD EXHIBITORS
BridgeBio
Philips Image Guided Therapy Devices
SILVER EXHIBITORS
Abbott
Boston Scientific
Regeneron
BRONZE EXHIBITORS
Alnylam – Amvuttra
Amgen
Arrowhead Pharmaceuticals
AstraZeneca
Boehringer-Ingelheim
Bristol Myers Squibb
GE Healthcare
HeartFlow
Ionis Pharmaceutical
J&J Medtech, Heart Recovery
Kiniksa Pharmaceuticals
Medtronic
Novartis
Pfizer
Teleflex
Shockwave Medical
Accreditation & Claiming Your CME & Reporting
CME/CE Accreditation & Designation
Complete the evaluation linked above to claim your CME and reporting for the course. You will receive your certificate via email within 2 weeks of submission.
Physicians:
Promedica International is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Promedica International designates this live activity for a maximum of 16.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurses:
The California BRN will accept AMA PRA Category 1™ credit toward license recertification. Nurses will choose this category of credit for their certificate. Review the CA BRN continuing education requirements here.
The American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ issued by organizations accredited by the ACCME for purposes of recertification. The American Academy of Nurse Practitioners Certified Program (AANPCP) and the American Association of Nurse Practitioners (AANP) also accept AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
Perfusionists:
The American Board of Cardiovascular Perfusion (ABCP) has approved a total of 19.7 Category 1 CEUs for perfusionists for Thursday, January 30 (9.6), and Friday, January 31 (10.1).
Physician Assistants:
NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. View NCCPA’s guidelines for CME here.
Registered Cardiovascular Invasive Specialist (RCIS):
CCI does not approve CEUs directly, however CCI will accept CEUs that have already been approved by accredited sponsors of the Accreditation Council for Continuing Medical Education (ACCME). RCIS attendees will claim the physician certificate option when completing the online evaluation and can use that certificate to claim CEUs from CCI. Click for more information from CCI.
ABIM MOC Accreditation:
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 16.25 Medical Knowledge MOC points and Patient Safety MOC credits in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
Faculty Disclosures
Please note that the timing below may change slightly as final adjustments are made to the program. Refresh the page to see updates.
PDFs of faculty slides will be available to course participants when approved for release by the speaker. Slides will generally be posted within 24 hours of presentation, to the best of our ability. You can access the slides by viewing the agenda below. If we have permission to share the slides, they will be hyperlinked in blue. Please refresh the page during the course to see additional posted slides.
Controversies 2025 Agenda
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Thursday, January 30th
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Friday, January 31st
7:00 – 7:50 AM
Registration, Continental Breakfast, & Visit Exhibits
Crystal Ballroom Foyer
7:50 – 7:55 AM
Welcome Address
Raj Makkar, MD, FACC
7:55 – 8:00 AM
CA ACC Welcome Address
John G. Harold, MD, MACC
8:00 – 8:30 AM
The Ronald G. Victor Memorial Lecture
A Brief History of Cardiology
Milton Packer, MD
Introduced by John G. Harold, MD, MACC
8:30 – 9:50 AM
Atherosclerosis and Dyslipidemia
Chair: Martha Gulati, MD, MPH, FACC
Panel: Dipti Itchhaporia, MD, MACC, Peter Toth, MD, PhD, Nathan Wong, MD, PhD
8:30 – 8:50 AM
LPA: A Nasty Cousin of LDL
Martha Gulati, MD, MPH, FACC
8:50 – 9:10 AM
Target for Lipid Lowering: LDL versus Non-HDL versus ApoB
Nathan Wong, PhD, FACC
9:10 – 9:30 AM
Severe Hypertriglyceridemia: Risks and Management
Peter Toth, MD, PhD
9:30 - 9:50 AM
State-of-the Art Lecture: Percutaneous Mechanical Circulatory Support
Navin K. Kapur, MD, FACC
9:50 – 10:10 AM
Break & Visit Exhibits
Crystal Ballroom Foyer
10:30 – 11:50 AM
Structural Heart Disease
Chairs: Raj Makkar, MD, FACC, Alfredo Trento, MD, FACC
Panel: Pedro Catarino, MD, Tarun Chakravarty, MD, David J. Cohen, MD, MSc, Gregory P. Fontana, MD, FACC, Martin Leon, MD, FACC, Michael Mack, MD, MACC
10:10 - 10:30 AM
Paving the Path: Key Lessons from My Experience with Transcatheter Valvular Interventions
Martin Leon, MD, FACC
10:30 – 10:50 AM
Debate: FDA Approval Pathway
• 10:30 – 10:40 AM
Tricuspid Device Approval - Too Much, Too Fast
Sanjay Kaul, MD, MPH, FACC
• 10:40 – 10:50 AM
Just Right – Our Patients Need These Devices
David J. Cohen, MD, MSc
10:50 – 11:10 AM
Debate: Mitral Regurgitation
• 10:50 – 11:00 AM
TEER Benefits All, Just Some More Than Others
Gregg Stone, MD, FACC
• 11:00 – 11:10 AM
Careful Case Selection Is the Key: We Should Not Treat a Lot of Moderate and Even Severe MR
Milton Packer, MD
11:10 – 11:30 AM
Debate: Bicuspid Aortic Valve Stenosis
• 11:10 – 11:20 AM
Open Heart Surgery Will Continue to be the Treatment of Choice for the Majority of Bicuspid Aortic Valve Stenosis for the Foreseeable Future
Pedro Catarino, MD
•11:20 – 11:30 AM
I Disagree, Transcatheter Therapies Will Treat the Majority of Such Patients by 2030
Hasan Jilaihawi, BSc (Hons), MD, MRCP (UK)
11:30 – 11:50 AM
Panel Adjudication on the Debates, Discussion on the State of Structural Interventions, Pre-Emptive TAVR, and Other Controversies
Panelists
11:50 AM – 1:00 PM
Hypertension
Chairs: Florian Rader, MD, MSc, FACC, Joseph Ebinger, MD
Panel: Richard Auchus, MD, PhD, Yufei Chen, MD, Jennifer L. Cluett, MD, Martha Gulati, MD, MPH, FACC, Stephen Juraschek, MD, PhD, Sabah Skaf, MD
11:50 AM – 12:25 PM
Debate: Management of Hyperaldosteronism
• 11:50 AM – 12:03 PM
Adrenalectomy Has the Best Outcomes!
Yufei Chen, MD
• 12:03 – 12:16 PM
Just Treat Medically to Cast a Wider Net!
Richard Auchus, MD, PhD
• 12:16 – 12:25 PM
Panel Discussion
12:25 – 1:00 PM
Debate: Cuffless Blood Pressure Devices-Are They Ready for Prime Time?
• 12:25 – 12:38 PM
No Way, Just Too Unreliable at This Point
Jennifer L. Cluett, MD
• 12:38 – 12:51 PM
Yes, Let's Implement!
Stephen Juraschek, MD, PhD
• 12:51 – 1:00 PM
Panel Discussion
1:00 – 2:00 PM
Lunch | Rodeo Ballroom
The lunch content is not CME/MOC accredited
Lunch Panel on Innovation
Moderators:
Gregory P. Fontana, MD, FACC, National Director, HCA Healthcare
Nirdesh K. Gupta, PhD, Managing Partner, Cedars-Sinai Technology Ventures
Frank Litvack, MD, FACC, Serial Innovator, Formerly Co-Director of the Cardiovascular Intervention Ctr, Cedars-Sinai Medical Center
Panelists:
William E. Cohn, MD, CMO, BiVACOR Inc
Neal Eigler, MD, CEO, V-Wave
Jason Fontana, PhD, Vice President of Global Marketing, Coronary and Renal Denervation General Manager, Medtronic
Nadim Geloo, MD, Senior Director Medical Affairs, Abbott
Benno Lansdorp, PhD, Director of Product Management, Philips IGT Devices, Coronary
Larry Wood, MBA, Corporate Vice President and Group President, Transcatheter Aortic Valve Replacement and Surgical Structural Heart, Edwards Lifesciences
2:00 – 2:20 PM
Keynote Lecture: New RNA Drugs for Heart Failure
Eduardo Marbán, MD, PhD, FACC
Introduced by Raj Makkar, MD, FACC
2:20 – 2:40 PM
Keynote Lecture: Medtech Innovation: Making America Healthy
Robert M. Califf, MD, MACC
2:40 – 2:50 PM
Panel Discussion / Q&A
Christine Albert, MPH, FACC, John G. Harold, MD, MACC, Martin Leon, MD, FACC, Michael Mack, MD, MACC, Raj Makkar, MD, FACC
2:50 – 3:50 PM
Update on Practice Changing Trials 2025
Chairs: Sanjay Kaul, MD, MPH, FACC, Raj Makkar, MD, FACC, Michael Farkouh, MD, MSc, FACC
Panel: Milton Packer, MD, Javed Butler, MD, MPH, MBA, Ahmad Masri, MD, MS, Gregg Stone, MD, Stuart Pocock, MA, PhD
2:50 – 3:10 PM
GIP/GLP-1RA: Beyond Glycemic Control, Weight Loss, and MACE Reduction
Discussants: Javed Butler, MD, MPH, MBA, Milton Packer, MD
3:10 – 3:30 PM
Transthyretin (TTR) Gene Silencers versus TTR Stabilizers - Insights from HELIOS-B (Vutrisiran) and ATTRibute-CM (Acoramidis) Trials in Management of Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Discussant: Ahmad Masri, MD, MS
3:30 – 3:50 PM
A Percutaneous Left Ventricular Assist Device Might Finally Have the Bragging Rights in Infarct-Related Cardiogenic Shock, but Is It Sufficient to Justify Its Wide Use? Insights from DanGer Shock Trial
Gregg Stone, MD
3:50 – 4:05 PM
Break & Visit Exhibits
Crystal Ballroom Foyer
4:05 – 4:25 PM
State of the Art Lecture: Management of Pulmonary Emboli in 2025
Rachel Rosovsky, MD, MPH
Introduced by Suhail Dohad, MD, FACC
4:25 – 4:35 PM
Panel Discussion / Q&A
Suhail Dohad, MD, FACC, Oren Friedman, MD, Rachel Rosovsky, MD, MPH
4:35 – 4:55 PM
Keynote Lecture: Future Interventions for the Heart and Other Organs
Kalyanam Shivkumar, MD, PhD, FACC
Introduced by Raj Makkar, MD
4:55 – 5:50 PM
Innovation in AI
Chairs: Sumeet Chugh, MD, FACC, Raj Makkar, MD, FACC
Panel: Damini Dey, PhD, Joseph Ebinger, MD, MS, FACC, Aakriti Gupta, MD, David Ouyang, MD, FACC, Rahul Sharma, MBBS, Piotr Slomka, MD, PhD, FACC
4:55 - 5:25 PM
Keynote Lecture: The AI Revolution in Clinical Practice: Present & Future
Sumeet Chugh, MD, FACC
5:25 - 5:40 PM
State of the Art Lecture: AI in the Future of Echocardiography and How We Get There
David Ouyang, MD, FACC
5:40 - 6:00 PM
Panel Discussion & Conclusion
7:00 – 7:55 AM
Registration, Continental Breakfast, & Visit Exhibit
Crystal Ballroom Foyer
7:55 – 8:00 AM
Welcome Back
Raj Makkar, MD, FACC
8:00 – 9:30 AM
Clinical Electrophysiology
Chairs: Sumeet Chugh, MD, FACC, Michael Shehata, MD, FACC, Christine M. Albert, MD, MPH, FACC
Panel: Nazem Akoum, MD, MS, FACC, FHRS, FAHA, Tina Baykaner, MD, PhD, Eric Braunstein, MD, Sanjay Dixit, MD, Edward Gerstenfeld, MD, FACC, Archana Ramireddy, MD
8:00 – 8:30 AM
Debate: In 2025, Who Should Get Catheter Ablation for Atrial Fibrillation?
• 8:00 – 8:15 AM
Pulsed Field Ablation (PFA) Is a Game Changer and ALL Patients with Atrial Fibrillation are Now Candidates
Edward Gerstenfeld, MD, FACC
• 8:15 – 8:30 AM
One Size Does Not Fit All: Only SELECTED Patients Should Go to the EP Lab
Sanjay Dixit, MD
8:30 – 9:00 AM
Debate: What is the Best Approach for Stroke Prophylaxis in Atrial Fibrillation?
• 8:30 – 8:45 AM
Pill-in-the-Pocket Oral Anticoagulation with Monitoring Devices is Ready for Prime Time
Nazem Akoum, MD, MS, FACC, FHRS, FAHA
• 8:45 - 9:00 AM
Don’t Mess with Success: Risk Factor-Based Long-Term DOACs are the Tried and Tested Approach
Archana Ramireddy, MD
9:00 - 9:30 AM
Debate: Modern Day Pacemakers: Which Technology is Best for Our Patients?
• 9:00 – 9:15 AM
Leadless Dual Chamber Pacemakers, Why Even Bother with Any Other Device?
Tina Baykaner, MD, PhD
• 9:15 – 9:30 AM
Pacemakers with Leads are Here to Stay and Physiologic Pacing Leads the Way
Eric Braunstein, MD
9:30 - 10:05 AM
Keynote Lecture: The Good the Bad, the Ugly of Clinical Trial Design: Lessons from a Master Statistician
Stuart Pocock, MA, PhD
Introduced by Raj Makkar, MD
10:00 - 10:25 AM
Break & Visit Exhibits
Crystal Ballroom Foyer
10:25 – 11:25 AM
Update in Cardiac Imaging: State-of-the-Art and Future
Chairs: Daniel Berman, MD, FACC, Robert Siegel, MD, FACC
Panel: Jeroen J. Bax, MD, PhD, FACC, John Friedman, MD, Hasan Jilaihawi, BSc (Hons), MD, MRCP (UK), Alan Kwan, MD, Sabah Skaf, MD, Piotr Slomka, MD, PhD, FACC
10:25 – 10:40 PM
Multimodality Imaging of Tricuspid Regurgitation
Jeroen J. Bax, MD, PhD, FACC
10:40 – 10:55 AM
The Future of Coronary CTA: New Approaches, Biomarkers, and Technologies
Damini Dey, PhD
10:55 – 11:25 AM
Debate: Coronary Plaque: Expanding Role in Guiding Patient Management
• 10:55 – 11:10 AM
Calcium Scanning is All You Need
Michael Blaha, MD, MPH
• 11:10 – 11:25 AM
Non-Calcified Plaque is the Future
Leandro Slipczuk Bustamante, MD, PhD, FACC
11:25 – 1:05 PM
Controversies in the Treatment of Coronary Artery Disease - Expert Views
Chairs: Raj Makkar, MD, FACC, Suhail Dohad, MD, FACC
Panel: Martin Leon, MD, FACC, Michael Mack, MD, MACC, Roxana Mehran, MD, FACC, Mamoo Nakamura, MD, Patrick Serruys, MD, PhD
11:25 – 11:55 AM
Keynote Lecture: Coronary Revascularization in 2040
Patrick Serruys, MD, PhD
Introduced by Raj Makkar, MD, FACC
11:55 AM - 12:10 PM
Derived Coronary Physiology- Even Better Than the Real Thing?
William Fearon, MD, FACC
12:10 – 12:25 PM
The Future of Pharmacotherapy for Coronary Artery Disease
Roxana Mehran, MD, FACC
12:25 – 12:55 PM
Debate: Should the ORBITA Trial be Practice Changing?
• 12:25 – 12:40 PM
Antianginals or Stents are Reasonable Alternatives for Patients with Symptomatic CAD
Rasha Al-Lamee, MA, MB, BS, PhD
• 12:40 – 12:55 PM
The Guidelines are Wrong: Everyone with Severe Proximal or Mid Vessel CAD Should Have PCI Regardless of Symptoms
Paul S. Teirstein, MD, FACC
12:55 – 1:05 PM
Debate Adjudication, Conversation on the State of Coronary Artery Disease Management
Michael Mack, MD, MACC, Raj Makkar, MD, FACC, Panelists
1:10 – 2:25 PM
Lunch | Rodeo Ballroom
This content is not CME/MOC accredited
Lunch Panel & Keynote Lecture
1:15 – 1:55 PM
Lunch Panel: Medical AI - The Healthcare Industry Perspective
Moderators:
Sumeet Chugh, MD, FACC, Director, EP, Director, Division of AI in Medicine, Cedars-Sinai Medical Center
Nirdesh K. Gupta, PhD, Managing Partner, Cedars-Sinai Technology Ventures
John G. Harold, MD, MACC, Past President, American College of Cardiology, Cedars-Sinai Medical Center
Panelists:
Lakshmi Prasad Dasi, PhD, Founder & CTO, DASI Simulations
David Formisano, MBA, Sr Digital Transformation Director, Coronary & Renal Denervation, Medtronic
Moleen Madziva Taitt, PhD, VP, Global Clinical Affairs, Viz.ai
Joseph Sokol, CEO & Founder, iCardio.ai
Charles Taylor, PhD, Founder, Board Member, HeartFlow
1:55 – 2:25 PM
Keynote Lecture: The Past, Present and Future of the Total Artificial Heart: Lessons from Texas
William E. Cohn, MD
Introduced by Gregory P. Fontana, MD, FACC
2:30 - 2:50PM
Keynote Lecture: The Role of Double-Blind Sham-Controlled Trials in Interventional Cardiology
Rasha Al-Lamee, MA, MB, BS, PhD
Introduced by Raj Makkar, MD, FACC
2:50 – 3:50 PM
Controversies in Advanced Heart Failure
Chairs: Jon Kobashigawa, MD, FACC, Michele Hamilton, MD, FACC
Panelists: Pedro Catarino, MD, Laura DiChiacchio, MD, PhD, Fardad Esmailian, MD, Dominic Emerson, MD, Tyler Gunn, MD, Asher Weisberg, MD
2:50 - 3:05 PM
Advances in Ex Vivo Perfusion
Tyler Gunn, MD
3:05 - 3:25 PM
Debate: Donation after Circulatory Death: DPP vs NRP
• 3:05 - 3:15 PM
Direct Procurement and Perfusion (DPP)
Laura DiChiacchio, MD, PhD
• 3:15 - 3:25 PM
Normothermic Regional Perfusion (NRP)
Asher Weisberg, MD
3:25 - 3:40 PM
Changing ABO Blood Type During Ex Vivo Perfusion
Fardad Esmailian, MD
3:40 - 3:50 PM
Panel Discussion
3:50 - 4:10 PM
Break & Visit Exhibits
Crystal Ballroom Foyer
4:10 - 4:30 PM
Keynote Lecture: Total Artificial Heart: European Experience
Michael Mack, MD, MACC
Introduced by Raj Makkar, MD, FACC
4:30 - 4:40 PM
Panel Discussion on Total Artificial Heart
Gregory P. Fontana, MD, FACC, Tyler Gunn, MD, Michael Mack, MD, MACC, Jaime Moriguchi, MD, FACC
4:40 – 5:00 PM
Keynote Lecture: Polygenic Risk Scoring for Cardiovascular Disease
Jamal S. Rana, MD, PhD, FACC
Introduced by John G. Harold, MD, MACC
5:00 – 6:00 PM
How to Diagnose INOCA
Chairs: C. Noel Bairey Merz, MD, MACC, Bruce Samuels, MD, FACC
Pantel: Rasha Al-Lamee, MA, MB, BS, PhD, John Beltrame, AM, BSc, BMBS, FRACP, PhD, FACC, William Fearon, MD, FACC, Aakriti Gupta, MD, FACC, Mamoo Nakamura, MD, FACC
5:00 – 5:05 PM
Welcome & Overview of Session Goals
C. Noel Bairey Merz, MD, MACC
5:05 – 5:15 PM
What is INOCA – What Is the Incidence, Prevalence and Proposed Etiology? What Is the Differential Diagnosis?
Janet Wei, MD, FACC, FAHA
5:15 – 5:30 PM
MINOCA, ANOCA and INOCA – What’s in a Name!
John F. Beltrame AM, BSc, BMBS, FRACP, PhD, FACC
5:30 – 5:40 PM
Moving the Needle: How Do We Get Interventional Cardiologists to Care About INOCA?
Bruce Samuels, MD
5:40 – 6:00 PM
Panel Discussion